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Research has characterised Tirzepatides beta cell incretin biology examining the additive versus synergistic insulin secretory responses from co-stimulation of GIPR and GLP-1R relative to selective monoagonism at either receptor, the glucose dependency of dual incretin-driven insulin secretion, first and second phase insulin secretory dynamics under dual receptor occupancy, and beta cell trophic biology under sustained Tirzepatide GIPR and GLP-1R co-stimulation

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Meanwhile, for the long-term management of patients with PCOS, in addition to medication, comprehensive interventions such as lifestyle modification, dietary control, and psychological support should be emphasized