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More serious, though rare, side effects can include pancreatitis, gallbladder problems, kidney problems, and severe allergic reactions

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The higher proportion of men vs women in the study may affect the generalisability of the findings to the broader population

A further consideration is the use of acid-suppressing medicines

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Indeed, the nearest significant NRF2 ChIP peak (IDR q-value 0.5) treated with indicated concentrations of A-485 or A-486 control for 7 days