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Ohira A, Yamaguchi S, Miyagi T, et al
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Not suitable for individuals with a history of acute or chronic muscle disorders, as it may exacerbate symptoms
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Standard dose escalation timeline The FDA-approved tirzepatide dose schedule follows a structured escalation pattern: Weeks 1 through 4: 2.5 mg once weekly (starting dose) Weeks 5 through 8: 5 mg once weekly Weeks 9 through 12: 7.5 mg once weekly Weeks 13 through 16: 10 mg once weekly Weeks 17 through 20: 12.5 mg once weekly (if needed) Week 21 onward: 15 mg once weekly (maximum dose) You reach 7.5 mg at approximately week 9
Funding This work was supported by the Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine (to HL) and the Albert B
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