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It functions as an obligatory cofactor for prolyl and lysyl hydroxylase, the enzymes that hydroxylate proline and lysine residues during collagen biosynthesis a role that is biochemically non-negotiable, meaning collagen cannot be properly synthesized without it

Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes

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Diabetes Care 39 , 214221 (2016)

I have seen patients lose weight and then require less immunosuppressant therapy for their condition. According to a systematic Obesity has been associated with worse autoimmune and inflammatory symptoms and with less favorable response to standard therapy for RA, added Ortiz

Typical doses: a tapering schedule like 40 mg for 5 days, 30 mg for 5 days, 20 mg for 5 days, etc