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Fasting insulin levels significantly decreased with tirzepatide (10 mg and 15 mg), and HOMA2-IR, a measure of insulin resistance, significantly decreased with tirzepatide (10 mg) compared to both placebo and dulaglutide

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From an experimental design perspective, the key hypothesis is not that the peptides duplicate each others effects, but rather that they might support different rate-limiting steps in repair, such as cell recruitment to the injury site, fibroblast function, extracellular matrix organization, angiogenesis, and the transition from inflammatory signaling to remodeling