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Contact your GP, study team, or supervising clinician if fatigue: Is severe enough to significantly impair daily functioning, work, or personal care Persists without any improvement despite the dose stabilising Is accompanied by dizziness, fainting, or palpitations , which may suggest dehydration or electrolyte disturbance Occurs alongside unexplained weight loss beyond expected levels , pallor, or breathlessness which could indicate nutritional anaemia Is associated with low mood, persistent sadness, or loss of motivation , as these may suggest depression rather than drug-related tiredness Develops alongside jaundice, dark urine, or abdominal pain , which warrant urgent assessment to exclude hepatic or pancreatic causes Seek urgent medical attention (call 999 or go to A&E) if you experience: Severe, persistent upper abdominal pain, particularly if it radiates to the back and is accompanied by vomiting these are potential symptoms of pancreatitis and require immediate assessment [12] Chest pain, severe dizziness, confusion, or an inability to keep any fluids down For urgent advice that does not require emergency services , contact NHS 111 (online at 111.nhs.uk or by telephone)

Symptom management: Both therapies can affect weight, mood, and energy levels

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761 High glycolytic activity in tumor cells reduces glucose concentrations within the TME

But stakeholders should understand exactly where they are in that process and make informed decisions accordingly," said Dustin Robinson, Esq., CPA, founding partner of LumaLex Law

Structural figures were prepared in UCSF Chimera 1.13.1 and PyMOL 2.1 ( The final refinement statistics are provided in Supplementary Table 1