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JHR symptoms include fever, chills, nausea and vomiting, headache, tachycardia (fast heartbeat), hypotension, and hyperventilation 1

These inhibitory effects of GLP-1 could be mediated by activation of vagal afferents in the distal small intestine or by hormonal effects on the NTS-DMV circuitry (123)

We further explored the miR-27b-5p expression profile

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Moreover, this glucose control intervention increased the risk of hypoglycemic episodes (73)