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In the obese state, adiponectin levels decrease as leptin levels increase
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10.1158/0008-5472.CAN-14-2211 124 KanarekN.KeysH
Some trial participants showed total body weight reductions in the 20-25% range, though these figures come from smaller, shorter studies and should be interpreted with caution until phase 3 data is published
Some side effects include gastrointestinal issues, dehydration, electrolyte abnormalities, loss of muscle mass and cardiovascular effects such as increased heart rate
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