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Well-tolerated by most skin types, including sensitive and acne-prone skin

The most frequently reported adverse effects are gastrointestinal issues, including nausea, vomiting, diarrhea, and constipation

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However, the compounded version was withdrawn from the market after pressure from the HHS and FDA

The fact that NRF2 is readily inducible in cultured astrocytes suggests that most pharmacological NRF2 activators may specifically target astrocytes in vivo, although there is still limited direct evidence for this

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