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pH: The copper-histidine coordination bond is most stable between pH 5 and 7

Experimental models have evaluated it for cytoprotective and regenerative activities across gastrointestinal mucosa, tendons, ligaments, muscles, bone, nervous tissue, and vascular endothelium

The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation

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This means your body cannot produce it on its own