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Trulicity (dulaglutide) can be taken if there are at least 3 days until the next scheduled dose

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Tesamorelin may have a more targeted fat-reduction effect, but Ipamorelin is often preferred for general weight loss and overall wellness due to its balanced impact and safety profile

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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)