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The preferential engagement of mitochondrial and bioenergetic pathways in the PFC, relative to the NAc, points to region-specific vulnerability to early-life stress and stress-THC co-exposure, aligning with prior evidence that peripubertal stress more strongly recruits metabolic gene networks in the PFC than in striatal regions [66]
Results are temporary
P = .04) total body weight loss compared with no hormone therapy
Together, these medications provide an integrated strategy to address ASCVD, HF, CKD, and obesity
Ongoing research continues to evaluate the broader physiological effects of triple agonist therapy, including potential impacts on cardiovascular health, liver metabolism, adipose tissue biology, and long-term metabolic adaptation
Glucose transporters in the small intestine in health and disease
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