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Nature 566 , 388392 (2019)

Key storage recommendations include: Store pens in their original carton to protect from light Keep the pen cap on when not in use Do not shake the pen Avoid storing near heat sources, in direct sunlight, or in vehicles Do not store in bathroom medicine cabinets where humidity and temperature fluctuate Transport in insulated cooling bags during travel, ensuring the medication does not freeze or directly contact ice packs Allow refrigerated pens to reach room temperature before injection to improve comfort Patients should be aware of the 21-day room-temperature limit for unused pens