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Importantly, the anticancer effects of platinating agents (especially cisplatin) are almost completely abolished by solvolysis in DMSO 5,18
& Solini, A
The pattern is more pronounced with CJC-1295 with DAC and resolves with dose reduction or cycling
If that methionine residue plays a role in receptor binding or biological activity, oxidation can reduce or eliminate the peptide effect entirely
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Patients with type 2 diabetes will likely need to take the GLP-1 agonist indefinitely
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