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A genome-wide pharmacogenomic study published in The Lancet Diabetes & Endocrinology identified two loci with significant effects on HbA1c response to GLP-1 RA treatment across 4,571 patients: the Gly168Ser variant in GLP1R (rs6923761), which reduces receptor signaling efficacy, and a low-frequency variant in ARRB1 (Thr370Met

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For 32.0% of individuals with initial HbA1c values of 5.0 mmol/mol, SGLT2i was expected to have a larger glycemic advantage versus GLP1-RA