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Clin Exp Rheumatol (2006) 24(1):836

Adverse reactions so far reported with these drugs include pancreatic insufficiency (Gier et al., 2012), gallstones (Rehfeld et al., 2018), gastroparesis (Sodhi et al., 2023), non-arteritic anterior ischemic optic neuropathy - NAION (Hathaway et al., 2024) and increase in diabetic retinopathy (Bain et al., 2018)

[1] [6] These symptoms are usually mild to moderate and tend to diminish over time, but in post-gastric bypass patients, they may be more pronounced or prolonged

and the protein coding genes SMCO1 , KDM4D , MT_TS1 , DTX3 , and NOTCH4 were among the main contributors to the correlation between metabolites and genes

Without a structured maintenance plan, most people regain 5070% of lost weight within 12 months of stopping

Thats not the way to address a big public health problem