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Often creates active metabolites Phase II metabolism: Conjugation, glucuronidation, acetylation etc Occurs in the liver and kidneys Involves other enzymes to CYP450 (various transferases) Often involves the addition of polar groups Often deactivates metabolites Excretion This involves the removal of the drug from the body

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Different flavonoids show opposite effects on melanin synthesis, and this is mainly dependent on the chemical structure of the flavonoids, including possessing only hydroxyl groups at the 4 position of the flavonoid skeleton ring B [72], 4- O -methylated flavonoids, 3 and 5- O -methyl groups [72], which are beneficial in promoting pigmentary hair regeneration

10.1159/000342534 90 LangE.QadriS

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After centrifugation for 5 min at 700 g, the supernatants were discarded and 100 L of each antibody diluted in PBS 5% FCS were added