is rybelsus a glp 1 RYBELSUS® Mechanism of Action Oral GLP-1 receptor agonist Rybelsus

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Guo et al

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It is a tripeptide, meaning it is composed of three amino acids: cysteine, glutamate, and glycine

In this large multisite study, utilizing data from six population-based databases, we found no evidence that GLP1-RA use is associated with an increased risk of thyroid cancer with follow-up ranging from 1.8-3.0 years, providing some reassurance to patients and clinicians about the short-term safety of these drugs, concluded the investigators

That separation is the main reason this combination is pharmacologically rational