The drugs ability to induce significant weight loss has been consistently observed in clinical trials, supporting its potential for long-term weight management
Catching trends early allows for intervention before significant reversal occurs
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The glucagon receptor component introduces a theoretical concern about bone density, as glucagon signalling has been associated with increased bone resorption in some preclinical models
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The resulting caloric deficit and weight loss which can be substantial over the course of treatment, as demonstrated in the SURMOUNT and STEP trial programmes can place considerable physiological stress on the body