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Vitamin B12: Can improve energy level
consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphatePTH monitoringnot as disease-modifying therapy in unselected CKD
Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F
Most current users inject AOD-9604 rather than taking it orally, so the trial data may underestimate what injectable protocols achieve
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