ROS production and associated inflammation are closely related to aging and numerous chronic diseases as diabetes, cardiovascular and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease
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Unlike other growth factors, IGF-1 acts as both a mitogen and a differentiation factor involved in the mitogenic and myogenic processes during muscle development, regeneration, or hypertrophy
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It mainly consists of three parallel mechanisms, i.e., extracellular signal regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs) and p38 MAPK 43
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