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Similarly, the HOMA-IR and TyG index were significantly lower in the high GLP-1 compared to the lower GLP-1 groups in the T2D population
2 The deterioration of insulin sensitivity and beta cell function, increased insulin clearance, high levels of visceral or liver fat, and worsening lipid profiles are key factors in T2DM
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Available from: Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes state-of-the-art
The gradual dose escalation protocol used in trials helped minimise the severity and duration of these effects, similar to the approach used with currently available treatments
Phenotypic outcomessuch as improved insulin sensitivity or enhanced thermogenesismay provide more robust translational anchors than circulating peptide levels alone
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