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The inhibition-excitation balance being off in the brain has been linked to anxiety, depression, autism, and schizophrenia
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This strategy is intended to help overcome the genetic heterogeneity that characterizes cancers like glioblastoma, where multiple subclones within a tumor can resist narrowly targeted treatments
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The mechanism of action indicates that SGLT2 is predominantly expressed in the kidney, with less expression in hepatic tissue (Bonner et al., 2015
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