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Ma L, Chen Y, Gong Q, Cheng Z, Ran C, Liu K, et al
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In acute myeloid leukemia, the m6A methyltransferase METTL3 and the reader protein IGF2BP3 maintain high-level serine synthesis by recognizing and stabilizing the mRNAs of SSP-related genes including ATF4, PHGDH and PSAT1, meeting the high metabolic demands of cancer cells, particularly leukemia stem/initiating cells ( 5.3 Post-translational modification regulation of enzyme activity The activity of metabolic enzymes involved in the de novo serine synthesis pathway is precisely modulated by post-translational modifications such as methylation, ubiquitination and deacetylation ( Figure 3 ), and such regulatory patterns exhibit cancer-type specificity
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Doctors know that diet and stress exacerbate both conditions, but they dont induce them
Based on the single dose tested for 2 , the estimated ED 50 is below 100 mg/kg
Each GHK-Cu treatment is prescribed by a board-certified physician and compounded in a licensed U.S
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