glp 1 discovery gila monster The of a digestion-slowing hormone in the monster's venom paved the way for Ozempic. When a Gila named Pebbles needed medicine in return, a pharmaceutical chemist pivoted to help Science's 2023 Breakthrough: GLP-1R Agonists

Maria Shadrina, Institute of Molecular Genetics (RAS), Russia

Oxford Academic

Zhao Z, Hua Z, Luo X, Li Y, Yu L, Li M, Lu C, Zhao T, Liu Y (2022) Application and pharmacological mechanism of methotrexate in rheumatoid arthritis

The ability to counteract side effects while leaving desired effects intact is a holy grail of modern medical research as it would improve therapeutic benefits for a number of drugs

While standard GLP-1s can sometimes cause lethargy due to reduced caloric intake, Tesofensine actively increases metabolic rate and often improves patient energy levels and focus

However, at the conclusion of their literature review, the authors reported that they did not find a consistent cytokine profile in ME/CFS