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Several factors contribute to the development of hyperpigmentation, with sun exposure being the primary culprit in most cases

Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

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Studies examining fibroblast and endothelial cell systems show increased phosphorylation of focal adhesion kinase and paxillin, two proteins central to cytoskeletal organization and cell adhesion signaling

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