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Available reports describe 5-Amino-1MQ as selective for NNMT within tested experimental panels, but those panels do not equal a complete off-target safety profile across all methyltransferases, non-methyltransferase proteins, cell types, exposure durations, or intracellular conditions

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It is the compound whose dose the blend is actually built around, which is why it takes the lions share of the vial

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While they are not FDA-approved themselves, they provide an alternative pathway for those who need personalized dosing under a providers care