As in our study, previous studies have shown that GLP-1RAs increase Nrf2 nuclear translocation and HO-1 expression in these tissues under stressful conditions, thereby increasing oxidative damage
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If you get this and its severe or persistent, make sure to speak to your doctor about reducing your dose or stopping treatment
Glutathione S -transferase Glutathione S -transferases ( GSTs ), previously known as ligandins , are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification