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J.MiarroJ.ContrerasC.Soto-MndezF.et al (2020)

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IGF-1's suppression of GH secretion through negative feedback indirectly improves metabolic function by reducing GH-mediated lipolysis and its associated insulin-antagonistic effects

The clinical asset (Retatrutide) sits at the center of this estate, and the estate is designed to defend that asset through launch and into the decade of follow-on products

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the apparent high incidence should be interpreted cautiously given the small denominator and high baseline AKI risk in advanced CKD