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A temporary worsening known as purging may occur within the first month and is usually temporary
DOI: 10.2174/138161211795428911 Santangelo, C., Vari, R., Scazzocchio, B., et al
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The oral glutathione supplement was slightly beneficial for skin lightening in particular subgroups, but the results were not statistically significant
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The choice between medications should rest primarily on efficacy data, tolerability, availability, and cost rather than the B12 inclusion, which is valuable in both formulations
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