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Varicocele also appears to damage the integrity of the blood-testicular barrier, a barrier that protects testicular cells by selectively regulating the movement of molecules from the blood into the testicular tissue

[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels

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Patch clamp electrophysiology studies showed significantly increased synapse density in hippocampal tissue