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It is most frequently experienced when starting the medication or increasing the dosage

These changes are clinically meaningful but generally less dramatic than those achieved with dedicated lipid-lowering therapies such as statins or PCSK9 inhibitors

Clinical trials showed that about 3% of people on the 0.5 mg dose and around 1% of those on the 1 mg dose reported experiencing this side effect

MOF-based nanoplatforms can also modulate anti-tumor immunity by influencing MDSCs in addition to nanocapsules, such as the (M+H)@ZIF/HA nanoparticles formed by the zeolite imidazolate framework-8 (ZIF-8) of the hyaluronic acid-modified mitoxantrone (MIT) and the DNA demethylating agent hydralazine (HYD) with pH response can convert cold tumors into antigen repertoire, stimulate robust immune responses and can effectively block MDSC-mediated T cell paralysis, triggering a strong cytotoxic T cell response to eliminate tumors (122)

People might feel nausea, vomiting, or diarrhea

But, even in its cheaper forms, the cost was a lot to bear