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Semaglutide for the treatment of obesity: A review of efficacy and safety
Foundayo (Orforglipron) Foundayo is the newest FDA-approved GLP-1 weight loss medication, approved in April 2026
JAMA 327:24232433 Rubino F, Cummings DE, Eckel RH et al (2025) Definition and diagnostic criteria of clinical obesity
At the same time, exercising on semaglutide can feel different than exercising before treatment
Oral semaglutide requires fasting administration (no food or drink except water for 30 minutes before and after the dose) and has higher gastrointestinal side-effect rates than injections because the drug saturates the gastric mucosa
That means they can have slightly different effects
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