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Building on this success, an expanding therapeutic pipelineincluding dual and triple agonists, amylin analogues, and other multimodal agentstargets complementary pathways and more closely aligns treatment with the biological complexity of obesity
Additionally, there is conflicting evidence in the literature concerning whether Semaglutide causes an inordinate amount of lean mass loss compared to situations where the same amount of weight is lost without the use of Semaglutide
Others benefit more from tirzepatide's dual mechanism, particularly if they have more significant insulin resistance or have not responded adequately to other GLP-1s
The distinctive response in the LH compared to the VMH may be explained by the different role these two areas have in the control of food intake