[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes
Jnne PA, Riely GJ, Gadgeel SM, Heist RS, Ou SI, Pacheco JM, et al
Regulatory Toxicology and Pharmacology
Mockett R, Sohal RS, Orr WC: Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hypoxia but not normoxia
Furthermore, stem cells often die off if the environment they are injected into is too inflamed
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