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Given the ancient origin of the Ca 2+ -based signaling, which evolutionary developed earlier than the mitochondrial apoptotic toolkit whose emergence cannot be dated back to the times earlier than eukaryogenesis and acquisition of an endosymbiotic mitochondrion, it can be assumed that the Ca 2+ toolkit takes over a key role in cell death signaling in terminally differentiated mitochondria-free erythrocytes

Glutathione acts as a scavenger, neutralizing free radicals and preventing them from causing cellular damage

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doi: 10.1101/cshperspect.a001651 178 MuellerALBrockmuellerAKunnumakkaraABShakibaeiM

ACSL4 binds to AA/AdA and catalyses the formation of AA/AdA-CoA