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Obesity and type 2 diabetes can exacerbate low testosterone levels, contributing to a cycle of metabolic dysfunction and hormonal imbalance

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The EC 50 -values for 2-chloro-N 6 -cyclopentyladenosine (CCPA), R-N 6 -phenylisopropyladenosine (R-PIA), 5-N-ethylcarboxamidoadenosine (NECA), and S-N 6 -phenylisopropyladenosine (S-PIA) were 0.10, 0.14, 0.24 and 12.9 M, respectively