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Adjustment phase: Increase gradually in increments of 250500 g depending on research parameters

Lose 14-15% of your body weight* *In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise

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CMS Transmittal 13673 (CR 14392) updated the MPFSDB effective April 6, 2026