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The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving 5% body weight reduction at week 72

A recent randomized controlled trial indicated that vitamin B12 supplementation significantly decreased serum levels of homocysteine compared to placebo, while no significant difference was revealed in between-group comparisons for fasting blood glucose, malondialdehyde, and liver steatosis (55)

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