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Although direct in vivo evidence for lichen mediated modulation of these pathways remains limited, similar regulatory effects on HIF-1 and TGF- signaling have been described for various natural secondary metabolites in non-lichen systems, providing mechanistic context
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Another emerging cell type is double negative PCa (DNPC)(Group 1, 2Group 4), which is negative for both AR and neuroendocrine markers and may represent an intermediate phenotype between AR expressing adenocarcinoma and the neuroendocrine phenotype (110)
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