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Through multiple pathways, amino acid metabolism determines the direction of macrophage polarization in MS, and together these mechanisms highlight the dual role of amino acid metabolism in MS pathogenesis and as a therapeutic target

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Simultaneously, the AMPK pathway, which may play a significant role in maintaining energy homeostasis, might be indirectly affected by IGF-1 analogs such as IGF-1 LR3

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doi: 10.20517/mtod.2022.13 79 JiangSZhuYChengCLiYMaTPengZet al