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SL formation begins with the condensation of L-serine and palmitic acid by serine palmitoyltransferase (SPT), the first and rate-limiting enzyme of this pathway

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doi: 10.1016/j.bbrc.2024.150946 62 YangSZhangTGeYYinLPuYLiangG

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However, the swift reaction is indicative of the operations scale and his influence within it