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Both NAPQI and ROS cause mitochondrial DNA damage, activation of the JNK signaling pathway, which further amplifies the mitochondrial ROS production, and causes the mitochondrial permeability transition (MPT) pore to open (Iorga et al., 2017)

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MiR-27a inhibits the expression of several lipid metabolic genes, including SREBP1-2, FASN, and PPAR/, by reducing lipid synthesis and increasing lipid secretion from cells 92