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It was initially discovered that GLP- 1 activates adenylate cyclase in tissue from the central nervous system (CNS) [53]
Its most distinctive physicochemical property is hydrolytic stability at low pH, unlike almost every peptide of comparable length, BPC-157 resists degradation in human gastric juice, a characteristic emphasised throughout the published work of Sikiric and colleagues (Curr Med Chem, 2012)
Cell death in cancer cell lines To evaluate the ability of leading candidate proteases to induce cell death via procaspase-1 and gasdermin D cleavage, we stably integrated X(PC) and X(GD), as well as catalytically inactive variants as negative controls, into cancer cell lines under doxycycline-induced expression (Fig
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Nevertheless, it has become a widely used research tool in metabolic diseases and muscle health, laying a critical foundation for mechanistic and therapeutic exploration in related fields
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