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One whole grapefruit or 200 mL of grapefruit juice is sufficient to cause clinically relevant increased systemic drug concentration and subsequent adverse effects.11 , 12 Seville oranges, (often used in marmalades), limes and pomelos also produce this interaction.13 15 Varieties of sweet orange, such as navel or valencia, do not contain furanocoumarins and do not produce this interaction.2 What determines which drugs are affected

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FOR YOUNG CHILDREN AND OLDER ADULTS SOURCE: Centers for Disease Control and Prevention

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