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Rheumatoid arthritis This is where the strongest clinical evidence exists right now
Lancet 368:1696-1705, 2006
Some adverse event reports were also related to patients being prescribed doses of compounded semaglutide or tirzepatide that were higher than those for the FDA-approved versions of these drugs, the FDA said
J Exp Med 192:10011014 Kehrer JP (2000) The Haber-Weiss reaction and mechanisms of toxicity
This tells us two things: There was no measurable placebo effect despite semaglutide-induce weight loss ( participants on this group lost on average ~10 lbs, as expected ) and other side effects that could have unblinded allocation
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