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These pathways are complementary, not interchangeable
Growth Hormone and Aging: Updated Review
Mendoza-ViverosCDGutirrez-PrezOBernad-BernadMJMedina-TorresLMonroy-BarretoMGimenoMet al
Tesamorelin + ipamorelin work through complementary GH-release mechanisms: tesamorelin activates GHRH receptors on pituitary somatotrophs, while ipamorelin selectively stimulates ghrelin receptors without cortisol or prolactin elevation
The study monitored for erythema, itching, scarring, atrophy, telangiectasias, and post-inflammatory hyperpigmentation, none of which were observed
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