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The accumulation of free radicals is one of the most important factors that accelerate this process

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Microglial NF-B activation under GSH-depleted conditions creates a pro-inflammatory loop where increased ROS promotes NF-B activation, which upregulates inflammatory cytokines and further stimulates oxidative stress (Liu et al., 2017

Studying these as a fixed-ratio blend lets a research model engage tissue-repair and inflammatory pathways simultaneously, while controlling for relative dosing across the four peptides