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Further, direct stimulation of the GLP-1 receptor on cholangiocytes can lead to enhanced cellular proliferation and an elevated likelihood of cholestasis [47]
10.1016/j.bbrc.2018.12.149 45 LiS.-L.WangZ.-M.XuC.CheF.-H.HuX.-F.CaoR.et al (2022)
The medication should be initiated at a 2.5 mg dose and, if necessary, gradually increased to the recommended maintenance dosages of 5 mg, 10 mg, or 15 mg based on the patients response and tolerance
The category allows the FDA to keep studying the drug in question, but generally prohibits compounders from selling it to the public until doctors have more proof of its safety and efficacy
Start with barely-perceptible stimulation and gradually increase intensity over days
Maas et al
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