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The mechanism by which GLP-1 agonists reduce alcohol intake in humans is currently unknown, though a recent RCT reported reduced alcohol cue reactivity in the nucleus accumbens (NAc), a key region associated with alcohols rewarding properties, after treatment with the GLP-1 agonist Exenatide 11

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Oral green tea preparations, by contrast, have been reviewed by Cochrane and found to produce only a small, statistically non-significant weight change

An argument can be made for early treatment in borderline cases, especially in patients with the identified high-risk characteristics for retinopathy progression with GLP-1/GIP agonist use ( Table 2 )

These are averages across large study populations, and individual results in physician-supervised programs vary considerably based on starting weight, metabolic health, adherence to lifestyle habits, and how well a particular medication is tolerated